Location and gene-specific effects of methylprednisolone acetate on mitigating IL1ß-induced inflammation in mature ovine explant knee tissue.

Barton, Kristen I; Heard, Bryan J; Chung, May; Sevick, Johnathan L; Martin, C Ryan; Achari, Yamini; Frank, Cyril B; Shrive, Nigel G; Hart, David A

Barton, Kristen I; Heard, Bryan J; Chung, May; Sevick, Johnathan L; Martin, C Ryan; Achari, Yamini; Frank, Cyril B; Shrive, Nigel G; Hart, David A.

Afiliação

Barton KI; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Heard BJ; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Chung M; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Sevick JL; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Martin CR; Schulich School of Engineering, University of Calgary, Calgary, AB, Canada.
Achari Y; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Frank CB; Section of Orthopaedics, Foothills Hospital, University of Calgary, Calgary, AB, Canada.
Shrive NG; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.

Inflamm Res ; 66(3): 239-248, 2017 Mar.

Article em En | MEDLINE | ID: mdl-27853846

Assuntos

Tecido Adiposo/efeitos dos fármacos; Cartilagem Articular/efeitos dos fármacos; Citocinas/genética; Metilprednisolona/análogos & derivados; RNA Mensageiro/metabolismo; Membrana Sinovial/efeitos dos fármacos; Adiponectina/genética; Tecido Adiposo/metabolismo; Animais; Cartilagem Articular/metabolismo; Feminino; Inflamação/metabolismo; Articulação do Joelho/efeitos dos fármacos; Articulação do Joelho/metabolismo; Leptina/genética; Metaloproteinases da Matriz/genética; Metilprednisolona/farmacologia; Acetato de Metilprednisolona; Nicotinamida Fosforribosiltransferase/genética; Ovinos; Membrana Sinovial/metabolismo; Receptor 4 Toll-Like/genética

Palavras-chave

Articular cartilage; Explant; Glucocorticoid; Infrapatellar fat pad; Methylprednisolone acetate; Synovium

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Sinovial / RNA Mensageiro / Metilprednisolona / Cartilagem Articular / Tecido Adiposo / Citocinas Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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