Chromatin-bound MDM2, a new player in metabolism.
Mol Cell Oncol
; 3(5): e1210560, 2016.
Article
em En
| MEDLINE
| ID: mdl-27857973
ABSTRACT
The oncoprotein MDM2 is recognized as a major negative regulator of the p53 tumor suppressor but growing evidence indicates that its oncogenic activities extend beyond p53. We show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article