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Copper Catalysis in Living Systems and In Situ Drug Synthesis.
Clavadetscher, Jessica; Hoffmann, Scott; Lilienkampf, Annamaria; Mackay, Logan; Yusop, Rahimi M; Rider, Sebastien A; Mullins, John J; Bradley, Mark.
Afiliação
  • Clavadetscher J; EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ, Edinburgh, UK.
  • Hoffmann S; University of Edinburgh/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK.
  • Lilienkampf A; EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ, Edinburgh, UK.
  • Mackay L; EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ, Edinburgh, UK.
  • Yusop RM; School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
  • Rider SA; University of Edinburgh/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK.
  • Mullins JJ; University of Edinburgh/BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK.
  • Bradley M; EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ, Edinburgh, UK.
Angew Chem Int Ed Engl ; 55(50): 15662-15666, 2016 12 12.
Article em En | MEDLINE | ID: mdl-27860120
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation strategies with applications ranging from polymer fabrication to bioconjugation. However, application in vivo has been limited by the inherent toxicity of the copper catalyst. Herein, we report the application of heterogeneous copper catalysts in azide-alkyne cycloaddition processes in biological systems ranging from cells to zebrafish, with reactions spanning from fluorophore activation to the first reported in situ generation of a triazole-containing anticancer agent from two benign components, opening up many new avenues of exploration for CuAAC chemistry.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azidas / Triazóis / Alcinos / Química Click / Reação de Cicloadição / Corantes Fluorescentes / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azidas / Triazóis / Alcinos / Química Click / Reação de Cicloadição / Corantes Fluorescentes / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article