Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease.

Davies, Danielle S; Ma, Jolande; Jegathees, Thuvarahan; Goldsbury, Claire

Davies, Danielle S; Ma, Jolande; Jegathees, Thuvarahan; Goldsbury, Claire.

Afiliação

Davies DS; Brain and Mind Centre, The University of Sydney, New South Wales, Australia.
Ma J; Discipline of Anatomy and Histology, School of Medical Sciences, The University of Sydney, New South Wales, Australia.
Jegathees T; Brain and Mind Centre, The University of Sydney, New South Wales, Australia.
Goldsbury C; Discipline of Anatomy and Histology, School of Medical Sciences, The University of Sydney, New South Wales, Australia.

Brain Pathol ; 27(6): 795-808, 2017 11.

Article em En | MEDLINE | ID: mdl-27862631

Assuntos

Envelhecimento/patologia; Doença de Alzheimer/patologia; Microglia/citologia; Autopsia; Encéfalo/patologia; Encéfalo/fisiologia; Feminino; Hipocampo/patologia; Humanos; Masculino; Microglia/patologia; Neocórtex/metabolismo; Proteínas tau/metabolismo

Palavras-chave

Alzheimer's disease; Iba1 protein; aging; confocal microscopy; dystrophic microglia; image analysis; imaging; immunofluorescence; microglia; morphology; post-mortem human brain tissue; tau; tau protein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Microglia / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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