Does direct stenting with drug-eluting stents improve outcome? A meta-analysis of 10,900 patients.
Catheter Cardiovasc Interv
; 90(2): 213-222, 2017 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-27862877
ABSTRACT
OBJECTIVES:
The aim of this study is to summarize the outcomes of patients undergoing direct stenting (DS) with drug-eluting stents (DES) compared to those who underwent balloon predilatation.BACKGROUND:
DS has been associated with improved outcomes in the bare-metal stent era. Although DS with DES implantation has been increasingly adopted in clinical practice, its safety and effectiveness remain controversial.METHODS:
The search criteria identified 546 studies in the Medline/PubMed, Cochrane, and EMBASE databases from 2001 to July 2014. From these, seven studies totaling 10,900 patients were selected. Summarized estimates [odds ratio (OR) and 95% confidence intervals] were obtained using a random-effects model. The primary outcomes were a composite of major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI), and repeat revascularization. The secondary outcomes included a composite of death and MI and the rates of target lesion revascularization (TLR).RESULTS:
Overall, 4101 (38%) and 6799 (62%) patients underwent DS with DES and balloon pre-dilatation, respectively. DS with DES reduced the likelihood of MACE (OR 0.81 [0.71-0.93]). Additionally, DS with DES was associated with reduced rates of death/MI (OR 0.76 [0.62-0.92]), and TLR (OR 0.66 [0.44-0.98]).CONCLUSIONS:
DS with DES is safe and may be associated with better outcomes in selected patients. © 2016 Wiley Periodicals, Inc.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Angioplastia com Balão
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Stents Farmacológicos
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Intervenção Coronária Percutânea
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article