Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.

Li, Xia; Fan, Xing-Xing; Jiang, Ze-Bo; Loo, Wings Ty; Yao, Xiao-Jun; Leung, Elaine Lai-Han; Chow, Louis Wc; Liu, Liang

Li, Xia; Fan, Xing-Xing; Jiang, Ze-Bo; Loo, Wings Ty; Yao, Xiao-Jun; Leung, Elaine Lai-Han; Chow, Louis Wc; Liu, Liang.

Afiliação

Li X; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.
Fan XX; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.
Jiang ZB; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.
Loo WT; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.
Yao XJ; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China.
Leung EL; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address: lhleung@must.edu.mo.
Chow LW; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address: wcchow@must.edu.mo.
Liu L; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address: lliu@must.edu.mo.

Pharmacol Res ; 115: 45-55, 2017 01.

Article em En | MEDLINE | ID: mdl-27864022

Assuntos

Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Receptores ErbB/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Naftoquinonas/farmacologia; Quinazolinas/farmacologia; Tiorredoxina Dissulfeto Redutase/metabolismo; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Linhagem Celular Tumoral; Gefitinibe; Ensaios de Triagem em Larga Escala/métodos; Humanos; Neoplasias Pulmonares/metabolismo; Mutação/efeitos dos fármacos; Recidiva Local de Neoplasia/tratamento farmacológico; Recidiva Local de Neoplasia/metabolismo; Fosforilação/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Apoptosis; Epidermal growth factor receptor; Non-small cell lung cancer; Reactive oxygen species; Shikonin; Thioredoxin reductases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Tiorredoxina Dissulfeto Redutase / Naftoquinonas / Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Receptores ErbB / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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