Vi capsular polysaccharide: Synthesis, virulence, and application.
Crit Rev Microbiol
; 43(4): 440-452, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-27869515
ABSTRACT
Vi capsular polysaccharide, a linear homopolymer of α-1,4-linked N-acetylgalactosaminuronate, is characteristically produced by Salmonella enterica serovar Typhi. The Vi capsule covers the surface of the producing bacteria and serves as an virulence factor via inhibition of complement-mediated killing and promoting resistance against phagocytosis. Furthermore, Vi also represents a predominant protective antigen and plays a key role in the development of vaccines against typhoid fever. Herein, we reviewed the latest advances associated with the Vi polysaccharide, from its synthesis and transport within bacterial cells, mechanisms involved in virulence, immunological characteristics, and applications in vaccine, as well as its purification and detection methods.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
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Salmonella typhi
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Cápsulas Bacterianas
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Fatores de Virulência
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article