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Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-ß signaling in chondrocytes.
Akagi, R; Akatsu, Y; Fisch, K M; Alvarez-Garcia, O; Teramura, T; Muramatsu, Y; Saito, M; Sasho, T; Su, A I; Lotz, M K.
Afiliação
  • Akagi R; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA; Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1-8-1, Inohana, Chuou, Chiba, 260-8677, Japan.
  • Akatsu Y; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA; Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1-8-1, Inohana, Chuou, Chiba, 260-8677, Japan.
  • Fisch KM; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.
  • Alvarez-Garcia O; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.
  • Teramura T; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.
  • Muramatsu Y; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.
  • Saito M; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA; Department of Orthopaedic Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan.
  • Sasho T; Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1-8-1, Inohana, Chuou, Chiba, 260-8677, Japan.
  • Su AI; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA.
  • Lotz MK; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA. Electronic address: mlotz@scripps.edu.
Osteoarthritis Cartilage ; 25(6): 943-951, 2017 06.
Article em En | MEDLINE | ID: mdl-27884645
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Cartilagem Articular / Fator de Crescimento Transformador beta / Ritmo Circadiano / Condrócitos / Osteoartrite do Joelho / Fatores de Transcrição ARNTL / Membro 1 do Grupo D da Subfamília 1 de Receptores Nucleares Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Cartilagem Articular / Fator de Crescimento Transformador beta / Ritmo Circadiano / Condrócitos / Osteoartrite do Joelho / Fatores de Transcrição ARNTL / Membro 1 do Grupo D da Subfamília 1 de Receptores Nucleares Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article