In situ forming pluronic® F127/chitosan hydrogel limits metronidazole transmucosal absorption.
Eur J Pharm Biopharm
; 112: 143-147, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-27890510
ABSTRACT
The objective of this work is to design topically-applied thermosensitive and mucoadhesive hydrogel containing metronidazole (MTZ) for the treatment of Trichomonas vaginalis infections. Hydrogel composed of pluronic® F127 (20wt%), chitosan (1wt%) and metronidazole MTZ (0.7wt%) mixture showed its ability to decrease by a factor 4 MTZ flux and apparent permeability absorption through vaginal mucosa. The impact of hydrogel on transmucosal penetration of MTZ was evaluated ex vivo on excised porcine vaginal mucosa mounted on Franz diffusion cell. The anti-T. vaginalis activity of MTZ formulated into F127/chitosan hydrogel was preserved since the viability curve evaluated in vitro was similar to MTZ solution.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poloxâmero
/
Hidrogéis
/
Quitosana
/
Metronidazol
/
Mucosa
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article