Inhibition of ERK/MAPK suppresses avian leukosis virus subgroup A and B replication.
Microb Pathog
; 102: 29-35, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27890652
ABSTRACT
We have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway contributes to subgroup J avian leukosis virus (ALV-J) replication and tumorigenicity. However, a role for ERK/MAPK signaling in ALV-A and ALV-B replication is unknown. In this study we successfully constructed and recovered a recombinant form of ALV-A strain GD13-1 which showed similarities in growth to the parental wild type virus in vitro. ALV subgroups J, A or B all triggered ERK2 activation in primary CEF cells. ERK/MAPK inhibition markedly suppressed ALV-A and ALV-B replication as shown by extremely low levels of viral transcription and virus protein production. This finding provides evidence that ERK/MAPK signaling responses play important roles in ALV replication and may represent novel drug targets for therapeutic intervention strategies.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
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Leucose Aviária
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Vírus da Leucose Aviária
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Sistema de Sinalização das MAP Quinases
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Inibidores de Proteínas Quinases
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article