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p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.
Franklin, Derek A; He, Yizhou; Leslie, Patrick L; Tikunov, Andrey P; Fenger, Nick; Macdonald, Jeffrey M; Zhang, Yanping.
Afiliação
  • Franklin DA; Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • He Y; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  • Leslie PL; Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Tikunov AP; Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  • Fenger N; Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Macdonald JM; Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  • Zhang Y; UNC Metabolomics Laboratory, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Sci Rep ; 6: 38067, 2016 11 30.
Article em En | MEDLINE | ID: mdl-27901115
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Via de Pentose Fosfato / Proteína Supressora de Tumor p53 / Fosfofrutoquinase-2 / Reparo do DNA / Glucose / Nucleosídeos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Via de Pentose Fosfato / Proteína Supressora de Tumor p53 / Fosfofrutoquinase-2 / Reparo do DNA / Glucose / Nucleosídeos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article