The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin &#945;IIbß3 Outside-in Signaling.

Battram, Anthony M; Durrant, Tom N; Agbani, Ejaife O; Heesom, Kate J; Paul, David S; Piatt, Raymond; Poole, Alastair W; Cullen, Peter J; Bergmeier, Wolfgang; Moore, Samantha F; Hers, Ingeborg

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbß3 Outside-in Signaling.

Battram, Anthony M; Durrant, Tom N; Agbani, Ejaife O; Heesom, Kate J; Paul, David S; Piatt, Raymond; Poole, Alastair W; Cullen, Peter J; Bergmeier, Wolfgang; Moore, Samantha F; Hers, Ingeborg.

Afiliação

Battram AM; From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Durrant TN; From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Agbani EO; From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Heesom KJ; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Paul DS; the McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.
Piatt R; the McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.
Poole AW; From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Cullen PJ; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Bergmeier W; the McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.
Moore SF; From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom.
Hers I; From the School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, United Kingdom. Electronic address: i.hers@bristol.ac.uk.

J Biol Chem ; 292(5): 1691-1704, 2017 02 03.

Article em En | MEDLINE | ID: mdl-27903653

Assuntos

Proteínas Ativadoras de GTPase/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fosfatos de Fosfatidilinositol/metabolismo; Receptores Citoplasmáticos e Nucleares/metabolismo; Transdução de Sinais/fisiologia; Substituição de Aminoácidos/genética; Animais; Plaquetas/metabolismo; Plaquetas/patologia; Células CHO; Cricetinae; Cricetulus; Modelos Animais de Doenças; Proteínas Ativadoras de GTPase/genética; Humanos; Camundongos; Camundongos Mutantes; Mutação de Sentido Incorreto; Fosfatidilinositol 3-Quinases/genética; Fosfatos de Fosfatidilinositol/genética; Complexo Glicoproteico GPIIb-IIIa de Plaquetas/genética; Receptores Citoplasmáticos e Nucleares/genética; Trombocitopenia/genética; Trombocitopenia/metabolismo; Trombocitopenia/patologia

Palavras-chave

GAP1IP4BP; Ras-related protein 1 (Rap1); Rasa3; cell signaling; integrin; phosphatidylinositide 3-kinase (PI3K); platelet

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores Citoplasmáticos e Nucleares / Fosfatos de Fosfatidilinositol / Fosfatidilinositol 3-Quinases / Proteínas Ativadoras de GTPase Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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