Impairment of decision-making in multiple sclerosis: A neuroeconomic approach.
Mult Scler
; 23(13): 1762-1771, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-27903935
ABSTRACT
OBJECTIVE:
To assess the decision-making impairment in patients with multiple sclerosis (MS) and how they relate to other cognitive domains.METHODS:
We performed a cross-sectional analysis in 84 patients with MS, and 21 matched healthy controls using four tasks taken from behavioral economics (1) risk preferences, (2) choice consistency, (3) delay of gratification, and (4) rate of learning. All tasks were conducted using real-world reward outcomes (food or money) in different real-life conditions. Participants underwent cognitive examination using the Brief Repeatable Battery-Neuropsychology.RESULTS:
Patients showed higher risk aversion (general propensity to choose the lottery was 0.51 vs 0.64, p = 0.009), a trend to choose more immediate rewards over larger but delayed rewards ( p = 0.108), and had longer reactions times ( p = 0.033). Choice consistency and learning rates were not different between groups. Progressive patients chose slower than relapsing patients. In relation to general cognitive impairments, we found correlations between impaired decision-making and impaired verbal memory ( r = 0.29, p = 0.009), visual memory ( r = -0.37, p = 0.001), and reduced processing speed ( r = -0.32, p = 0.001). Normalized gray matter volume correlated with deliberation time ( r = -0.32, p = 0.005).CONCLUSION:
Patients with MS suffer significant decision-making impairments, even at the early stages of the disease, and may affect patients' quality and social life.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Assunção de Riscos
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Tomada de Decisões
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Disfunção Cognitiva
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Aprendizagem
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Esclerose Múltipla
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article