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A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis.
Bertheas, M F; Jaubert, J; Vasselon, C; Reynaud, J; Pomier, G; Le Petit, J C; Hagemeijer, A; Brizard, C P.
Afiliação
  • Bertheas MF; Departement d'Hématologie, Immunologie et Cytogénétique, Centre Hospitalier et Universitaire de Saint-Etienne, France.
Cancer Genet Cytogenet ; 42(1): 67-73, 1989 Oct 01.
Article em En | MEDLINE | ID: mdl-2790748
The t(8;16)(p11;p13) is a recently described new chromosome rearrangement of acute nonlymphocytic leukemia (ANLL). It appears to be specifically associated with acute monoblastic (AML-M5) or unusual myelomonocytic leukemia with prominent erythrophagocytosis in the leukemic cells. A complex t(3;8;17)(q27;p11;q12) is reported in a case of acute monoblastic leukemia with erythrophagocytosis. Sixteen cases of this t(8;16) and two other variant translocations are reviewed. The pathogenetic mechanism of the variant translocations is discussed, suggesting that the der(8) is a consistent recombinant.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fagocitose / Translocação Genética / Cromossomos Humanos Par 3 / Cromossomos Humanos Par 8 / Cromossomos Humanos Par 17 / Leucemia Monocítica Aguda Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 1989 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fagocitose / Translocação Genética / Cromossomos Humanos Par 3 / Cromossomos Humanos Par 8 / Cromossomos Humanos Par 17 / Leucemia Monocítica Aguda Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 1989 Tipo de documento: Article