Your browser doesn't support javascript.
loading
New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives.
Lolignier, Stéphane; Gkika, Dimitra; Andersson, David; Leipold, Enrico; Vetter, Irina; Viana, Felix; Noël, Jacques; Busserolles, Jérôme.
Afiliação
  • Lolignier S; Clermont Université, Université d'Auvergne, Pharmacologie fondamentale et clinique de la douleur, 63000 Clermont-Ferrand, France.
  • Gkika D; Inserm, U 1107, Neuro-Dol, 63000 Clermont-Ferrand, France.
  • Andersson D; Laboratoire de Physiologie cellulaire, Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Université Lille 1, 59655 Villeneuve d'Ascq Cedex, France.
  • Leipold E; King's College London, Wolfson Centre for Age-Related Diseases Wolfson Wing, SE1 1UL London, United Kingdom.
  • Vetter I; Institut für Biochemie und Biophysik, D-07745 Jena, Germany.
  • Viana F; Institute for Molecular Bioscience and School of Pharmacy, University of Queensland, Brisbane, Queensland 4072, Australia.
  • Noël J; Instituto de Neurociencias de Alicante Universidad Miguel Hernandez/CSIC Avda. S. Ramón y Cajal s.n. San Juan de Alicante, 03550 Alicante, Spain.
  • Busserolles J; Université Côte d'Azur, CNRS UMR 7275, Institut de Pharmacologie Moléculaire et Cellulaire, France, and jerome.busserolles@udamail.fr jnoel@unice.fr.
J Neurosci ; 36(45): 11435-11439, 2016 11 09.
Article em En | MEDLINE | ID: mdl-27911746
Cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane. This transformation into electrical signals is followed by the subsequent propagation of action potentials in cold-sensitive afferent nerve fibers. A large array of ion channels shapes this process; however, the precise contribution of specific ion channel subtypes to cold perception and cold pain remains elusive. This review aims at giving an update on our current understanding of the role played by TRPs, leak K+ and voltage-gated Na+ and K+ channels in the transduction of cold by nociceptors and in cold-induced pain.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Sensação Térmica / Nociceptores / Temperatura Baixa / Percepção da Dor / Canais Iônicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Sensação Térmica / Nociceptores / Temperatura Baixa / Percepção da Dor / Canais Iônicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article