Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers.
Chem Pharm Bull (Tokyo)
; 65(2): 204-207, 2017 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-27916782
ABSTRACT
A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B-D (2-4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 cancer cells with IC50 values ranging from 0.51 to 0.66 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ensaios de Seleção de Medicamentos Antitumorais
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Extratos Vegetais
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Ophiopogon
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Tubérculos
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Isoflavonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article