Inhibition of protein kinase C induces differentiation of neuroblastoma cells.
FEBS Lett
; 255(1): 184-6, 1989 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-2792369
ABSTRACT
It is shown that 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), a specific inhibitor of protein kinase C, induces neuritogenesis in neuro 2a cells. The percentage of differentiated cells was 9%, 20%, 59% and 85% at 0, 17, 85 and 500 microM H7, respectively. The number of neurites cell increased 2-, 8- and 14-fold over the controls for 17, 85 and 500 microM H7, respectively. These results indicate that protein kinase C plays a key role in the control of differentiation of neural cells and that its specific inhibition may be of basic as well as of practical importance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Proteína Quinase C
/
Isoquinolinas
/
Neuroblastoma
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article