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The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).
Matz, Melissa; Coleman, Michel P; Sant, Milena; Chirlaque, Maria Dolores; Visser, Otto; Gore, Martin; Allemani, Claudia.
Afiliação
  • Matz M; Cancer Survival Group, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: Melissa.Matz@LSHTM.ac.uk.
  • Coleman MP; Cancer Survival Group, London School of Hygiene & Tropical Medicine, London, UK.
  • Sant M; Department of Preventive and Predictive Medicine, Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Chirlaque MD; Department of Epidemiology, Regional Health Council, IMIB, Arrixaca, Murcia, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Department of Health and Social Sciences, Murcia University, Murcia, Spain.
  • Visser O; Department of Registration, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
  • Gore M; The Royal Marsden NHS Foundation Trust, London, UK.
  • Allemani C; Cancer Survival Group, London School of Hygiene & Tropical Medicine, London, UK.
Gynecol Oncol ; 144(2): 405-413, 2017 Feb.
Article em En | MEDLINE | ID: mdl-27931752
OBJECTIVE: Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. METHODS: The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. RESULTS: During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. CONCLUSIONS: The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article