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Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.
Huang, Shar-Yin N; Williams, Jessica S; Arana, Mercedes E; Kunkel, Thomas A; Pommier, Yves.
Afiliação
  • Huang SN; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
  • Williams JS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
  • Arana ME; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
  • Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
  • Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA pommier@nih.gov.
EMBO J ; 36(3): 361-373, 2017 02 01.
Article em En | MEDLINE | ID: mdl-27932446
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / DNA / DNA Topoisomerases Tipo I / Proteínas de Saccharomyces cerevisiae / Quebras de DNA de Cadeia Dupla Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / DNA / DNA Topoisomerases Tipo I / Proteínas de Saccharomyces cerevisiae / Quebras de DNA de Cadeia Dupla Idioma: En Ano de publicação: 2017 Tipo de documento: Article