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Establishment of induced pluripotent stem cell (iPSC) line from an 8-year old female patient with ischemic Moyamoya disease.
Cardano, Marina; Marsoner, Fabio; Zasso, Jacopo; Marcatili, Matteo; Karnavas, Thodoris; Lanterna, Luigi Andrea; Conti, Luciano.
Afiliação
  • Cardano M; Laboratory of Stem Cell Biology, Centre for Integrative Biology-CIBIO, Università degli Studi di Trento, Trento, Italy.
  • Marsoner F; Laboratory of Stem Cell Biology, Centre for Integrative Biology-CIBIO, Università degli Studi di Trento, Trento, Italy. Electronic address: fmar@uni-bonn.de.
  • Zasso J; Laboratory of Stem Cell Biology, Centre for Integrative Biology-CIBIO, Università degli Studi di Trento, Trento, Italy.
  • Marcatili M; Laboratory of Stem Cell Biology, Centre for Integrative Biology-CIBIO, Università degli Studi di Trento, Trento, Italy; Department of Health Sciences, Università Degli Studi di Milano, Milan, Italy; Department of Mental Health, San Paolo Hospital, Milan, Italy.
  • Karnavas T; Chromatin Dynamics Unit, San Raffaele University and Research Institute, Milan, Italy. Electronic address: tk2708@cumc.columbia.edu.
  • Lanterna LA; Department of Neuroscience and Surgery of the Nervous System, Papa Giovanni XXIII Hospital, Bergamo, Italy. Electronic address: l.lanterna@gmail.com.
  • Conti L; Laboratory of Stem Cell Biology, Centre for Integrative Biology-CIBIO, Università degli Studi di Trento, Trento, Italy. Electronic address: Luciano.Conti@unitn.it.
Stem Cell Res ; 17(3): 619-622, 2016 11.
Article em En | MEDLINE | ID: mdl-27934593
Peripheral blood mononuclear cells (PBMCs) were collected from an 8-year old female patient affected by ischemic Moyamoya disease (MMD). Patient's PBMCs were reprogrammed using Sendai virus particles delivering the four Yamanaka factors. The footprint free hiPSC line expressed the major pluripotency markers and exhibited a normal karyotype. Cells were competent to give rise to progeny of differentiated cells belonging to the 3 germ layers. This hiPSC line represents a good tool to in vitro model MMD in order to shed light on the cellular and molecular mechanisms responsible for the occurrence of this syndrome.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Doença de Moyamoya Tipo de estudo: Prognostic_studies Limite: Child / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Doença de Moyamoya Tipo de estudo: Prognostic_studies Limite: Child / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article