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Self-aggregating 1.8kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon-skipping oligonucleotides.
Chiper, Manuela; Tounsi, Nassera; Kole, Ryszard; Kichler, Antoine; Zuber, Guy.
Afiliação
  • Chiper M; Molecular and Pharmaceutical Engineering of Biologics, CNRS - Université de Strasbourg UMR 7242, Boulevard Sebastien Brant, 67412 Illkirch, France; Faculté de Pharmacie - Université de Strasbourg, 74 Route du Rhin, F-67400 Illkirch, France.
  • Tounsi N; Faculté de Pharmacie - Université de Strasbourg, 74 Route du Rhin, F-67400 Illkirch, France; Laboratory of Therapeutic Innovation UMR 7200, CNRS - Université de Strasbourg, France.
  • Kole R; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, United States.
  • Kichler A; Faculté de Pharmacie - Université de Strasbourg, 74 Route du Rhin, F-67400 Illkirch, France; Laboratoire de Conception et d'Application de Molécules Bioactives, CNRS - Université de Strasbourg UMR 7199, France; Genethon, 91000 Evry, France.
  • Zuber G; Molecular and Pharmaceutical Engineering of Biologics, CNRS - Université de Strasbourg UMR 7242, Boulevard Sebastien Brant, 67412 Illkirch, France. Electronic address: zuber@unistra.fr.
J Control Release ; 246: 60-70, 2017 01 28.
Article em En | MEDLINE | ID: mdl-27956144
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Polietilenoimina / DNA / RNA Mensageiro / Técnicas de Transferência de Genes / RNA Interferente Pequeno / Oligonucleotídeos Fosforotioatos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Polietilenoimina / DNA / RNA Mensageiro / Técnicas de Transferência de Genes / RNA Interferente Pequeno / Oligonucleotídeos Fosforotioatos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article