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Salvage Therapy with Ceftolozane-Tazobactam for Multidrug-Resistant Pseudomonas aeruginosa Infections.
Castón, Juan José; De la Torre, Álvaro; Ruiz-Camps, Isabel; Sorlí, María Luisa; Torres, Vicente; Torre-Cisneros, Julián.
Afiliação
  • Castón JJ; Clinical Unit of Infectious Diseases, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica (IMIBIC), Córdoba, Spain.
  • De la Torre Á; Spanish Network for the Research in Infectious Diseases (REIPI RD12/2015), Instituto de Salud Carlos III, Madrid, Spain.
  • Ruiz-Camps I; Service of Anesthesiology and Reanimation, Hospital de Jaen, Jaen, Spain.
  • Sorlí ML; Department of Infectious Diseases, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Torres V; Department of Infectious Diseases, Hospital del Mar, Barcelona, Spain.
  • Torre-Cisneros J; Service of Anesthesia and Reanimation, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
Antimicrob Agents Chemother ; 61(3)2017 03.
Article em En | MEDLINE | ID: mdl-27956431
ABSTRACT
Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRPA) present a major problem for therapeutic management. We report here our experience with 12 patients with a severe MDRPA infection (6 of which were pneumonia) who received salvage therapy with ceftolozane-tazobactam after inappropriate empirical treatment and/or suboptimal targeted treatment. Although 10 of the 12 patients (83.3%) experienced septic shock, only 3 patients (25%) died during the follow-up period. Microbiological cure in 7 patients (58.3%) was observed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Choque Séptico / Cefalosporinas / Ácido Penicilânico / Pneumonia Bacteriana / Farmacorresistência Bacteriana Múltipla / Antibacterianos Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Infecções por Pseudomonas / Choque Séptico / Cefalosporinas / Ácido Penicilânico / Pneumonia Bacteriana / Farmacorresistência Bacteriana Múltipla / Antibacterianos Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article