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Human SOD1 ALS Mutations in a Drosophila Knock-In Model Cause Severe Phenotypes and Reveal Dosage-Sensitive Gain- and Loss-of-Function Components.
Sahin, Asli; Held, Aaron; Bredvik, Kirsten; Major, Paxton; Achilli, Toni-Marie; Kerson, Abigail G; Wharton, Kristi; Stilwell, Geoff; Reenan, Robert.
Afiliação
  • Sahin A; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912.
  • Held A; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912.
  • Bredvik K; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912.
  • Major P; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912.
  • Achilli TM; Department of Biology, Rhode Island College, Providence, Rhode Island 02908.
  • Kerson AG; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912.
  • Wharton K; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912.
  • Stilwell G; Department of Biology, Rhode Island College, Providence, Rhode Island 02908.
  • Reenan R; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912 robert_reenan@brown.edu.
Genetics ; 205(2): 707-723, 2017 02.
Article em En | MEDLINE | ID: mdl-27974499
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Drosophila / Superóxido Dismutase-1 / Esclerose Lateral Amiotrófica Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Drosophila / Superóxido Dismutase-1 / Esclerose Lateral Amiotrófica Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article