Childhood trauma and emotional processing circuits in schizophrenia: A functional connectivity study.
Schizophr Res
; 184: 69-72, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-27979699
ABSTRACT
Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Córtex Cerebral
/
Emoções
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Conectoma
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Adultos Sobreviventes de Eventos Adversos na Infância
/
Tonsila do Cerebelo
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article