Functional Segregation of Overlapping Genes in HIV.

Fernandes, Jason D; Faust, Tyler B; Strauli, Nicolas B; Smith, Cynthia; Crosby, David C; Nakamura, Robert L; Hernandez, Ryan D; Frankel, Alan D

Fernandes, Jason D; Faust, Tyler B; Strauli, Nicolas B; Smith, Cynthia; Crosby, David C; Nakamura, Robert L; Hernandez, Ryan D; Frankel, Alan D.

Afiliação

Fernandes JD; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA; Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA 94158, USA.
Faust TB; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA; Tetrad Program, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
Strauli NB; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94158, USA.
Smith C; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
Crosby DC; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
Nakamura RL; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
Hernandez RD; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Frankel AD; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: frankel@cgl.ucsf.edu.

Cell ; 167(7): 1762-1773.e12, 2016 Dec 15.

Article em En | MEDLINE | ID: mdl-27984726

Assuntos

Evolução Biológica; HIV-1/genética; Produtos do Gene tat do Vírus da Imunodeficiência Humana/genética; Entropia; Aptidão Genética; Infecções por HIV/virologia; Humanos; Mutação; Fases de Leitura Aberta; Produtos do Gene rev do Vírus da Imunodeficiência Humana/genética

Palavras-chave

HIV; Rev; Tat; alanine scanning; deep mutational scanning; evolution; overlapping reading frames; overprinting; viral evolution; virus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Evolução Biológica / Produtos do Gene tat do Vírus da Imunodeficiência Humana Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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