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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
Wahl, Simone; Drong, Alexander; Lehne, Benjamin; Loh, Marie; Scott, William R; Kunze, Sonja; Tsai, Pei-Chien; Ried, Janina S; Zhang, Weihua; Yang, Youwen; Tan, Sili; Fiorito, Giovanni; Franke, Lude; Guarrera, Simonetta; Kasela, Silva; Kriebel, Jennifer; Richmond, Rebecca C; Adamo, Marco; Afzal, Uzma; Ala-Korpela, Mika; Albetti, Benedetta; Ammerpohl, Ole; Apperley, Jane F; Beekman, Marian; Bertazzi, Pier Alberto; Black, S Lucas; Blancher, Christine; Bonder, Marc-Jan; Brosch, Mario; Carstensen-Kirberg, Maren; de Craen, Anton J M; de Lusignan, Simon; Dehghan, Abbas; Elkalaawy, Mohamed; Fischer, Krista; Franco, Oscar H; Gaunt, Tom R; Hampe, Jochen; Hashemi, Majid; Isaacs, Aaron; Jenkinson, Andrew; Jha, Sujeet; Kato, Norihiro; Krogh, Vittorio; Laffan, Michael; Meisinger, Christa; Meitinger, Thomas; Mok, Zuan Yu; Motta, Valeria; Ng, Hong Kiat.
Afiliação
  • Wahl S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
  • Drong A; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Lehne B; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
  • Loh M; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  • Scott WR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • Kunze S; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • Tsai PC; Institute of Health Sciences, P.O. Box 5000, FI-90014 University of Oulu, Finland.
  • Ried JS; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648, Singapore.
  • Zhang W; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • Yang Y; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
  • Tan S; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
  • Fiorito G; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Franke L; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  • Guarrera S; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Kasela S; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • Kriebel J; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Richmond RC; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • Adamo M; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
  • Afzal U; Human Genetics Foundation-Torino, Torino, Italy.
  • Ala-Korpela M; Medical Sciences Department, University of Torino, Torino, Italy.
  • Albetti B; University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, The Netherlands.
  • Ammerpohl O; Human Genetics Foundation-Torino, Torino, Italy.
  • Apperley JF; Medical Sciences Department, University of Torino, Torino, Italy.
  • Beekman M; Estonian Genome Center, University of Tartu, Riia 23b, 51010 Tartu, Estonia.
  • Bertazzi PA; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia.
  • Black SL; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
  • Blancher C; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Bonder MJ; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
  • Brosch M; MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Carstensen-Kirberg M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK.
  • de Craen AJ; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • de Lusignan S; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Dehghan A; Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.
  • Elkalaawy M; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Fischer K; Computational Medicine, School of Social and Community Medicine, University of Bristol and Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Franco OH; EPIGET Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Gaunt TR; Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel Campus, Kiel, Germany.
  • Hampe J; Centre for Haematology, Department of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, UK.
  • Hashemi M; Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands.
  • Isaacs A; EPIGET Lab, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Jenkinson A; Section of Infectious Diseases and Immunity, Department of Medicine, Imperial College London, London W12 0NN, UK.
  • Jha S; High Throughput Genomics-Oxford Genomic Centre, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Kato N; University of Groningen, University Medical Center Groningen, Department of Genetics, 9700 RB Groningen, The Netherlands.
  • Krogh V; Medical Department 1, University Hospital of the Technical University Dresden, Dresden, Germany.
  • Laffan M; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
  • Meisinger C; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • Meitinger T; Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Mok ZY; Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7PX, UK.
  • Motta V; Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands.
  • Ng HK; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK.
Nature ; 541(7635): 81-86, 2017 01 05.
Article em En | MEDLINE | ID: mdl-28002404
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Massa Corporal / Metilação de DNA / Epigênese Genética / Diabetes Mellitus Tipo 2 / Adiposidade / Estudo de Associação Genômica Ampla / Epigenômica / Obesidade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Asia / Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Massa Corporal / Metilação de DNA / Epigênese Genética / Diabetes Mellitus Tipo 2 / Adiposidade / Estudo de Associação Genômica Ampla / Epigenômica / Obesidade Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Asia / Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article