Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity.

Peng, Wenjie; de Vries, Robert P; Grant, Oliver C; Thompson, Andrew J; McBride, Ryan; Tsogtbaatar, Buyankhishig; Lee, Peter S; Razi, Nahid; Wilson, Ian A; Woods, Robert J; Paulson, James C

Peng, Wenjie; de Vries, Robert P; Grant, Oliver C; Thompson, Andrew J; McBride, Ryan; Tsogtbaatar, Buyankhishig; Lee, Peter S; Razi, Nahid; Wilson, Ian A; Woods, Robert J; Paulson, James C.

Afiliação

Peng W; Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
de Vries RP; Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Grant OC; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Thompson AJ; Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
McBride R; Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Tsogtbaatar B; Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Lee PS; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Razi N; Departments of Cell and Molecular Biology, Chemical Physiology, and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Woods RJ; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
Paulson JC; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.

Cell Host Microbe ; 21(1): 23-34, 2017 Jan 11.

Article em En | MEDLINE | ID: mdl-28017661

Assuntos

Glicoproteínas de Hemaglutininação de Vírus da Influenza/metabolismo; Vírus da Influenza A Subtipo H3N2/metabolismo; Receptores Virais/metabolismo; Ligação Viral; Animais; Linhagem Celular; Cães; Galactanos/metabolismo; Células HEK293; Humanos; Vírus da Influenza A Subtipo H1N1/genética; Vírus da Influenza A Subtipo H1N1/metabolismo; Vírus da Influenza A Subtipo H3N2/genética; Vírus da Influenza A Subtipo H3N8/metabolismo; Virus da Influenza A Subtipo H5N1/metabolismo; Células Madin Darby de Rim Canino; Simulação de Dinâmica Molecular; Ácido N-Acetilneuramínico/metabolismo; Polissacarídeos/metabolismo; Especificidade da Espécie

Palavras-chave

H3N2; airway; bidentate binding; chemo-enzymatic synthesis; extended branched glycans; hemagglutinin; influenza virus; poly-N-acetyl-lactosamine; receptor specificity; sialoside microarray

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Virais / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Vírus da Influenza A Subtipo H3N2 / Ligação Viral Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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