Cheminformatics Modeling of Adverse Drug Responses by Clinically Relevant Mutants of Human Androgen Receptor.

Paul, Naman; Carabet, Lavinia A; Lallous, Nada; Yamazaki, Takeshi; Gleave, Martin E; Rennie, Paul S; Cherkasov, Artem

Paul, Naman; Carabet, Lavinia A; Lallous, Nada; Yamazaki, Takeshi; Gleave, Martin E; Rennie, Paul S; Cherkasov, Artem.

Afiliação

Paul N; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.
Carabet LA; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.
Lallous N; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.
Yamazaki T; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.
Gleave ME; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.
Rennie PS; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.
Cherkasov A; Vancouver Prostate Centre, Department of Urologic Sciences, Faculty of Medicine, The University of British Columbia , 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.

J Chem Inf Model ; 56(12): 2507-2516, 2016 12 27.

Article em En | MEDLINE | ID: mdl-28024400

Assuntos

Antagonistas de Receptores de Andrógenos/farmacologia; Feniltioidantoína/análogos & derivados; Mutação Puntual/efeitos dos fármacos; Receptores Androgênicos/metabolismo; Antagonistas de Receptores de Andrógenos/química; Androgênios/química; Androgênios/farmacologia; Benzamidas; Humanos; Masculino; Modelos Moleculares; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Nitrilas; Feniltioidantoína/química; Feniltioidantoína/farmacologia; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Receptores Androgênicos/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Feniltioidantoína / Receptores Androgênicos / Mutação Puntual / Antagonistas de Receptores de Andrógenos Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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