Pyran Rings Containing Polyketides from Penicillium raistrickii.
Mar Drugs
; 15(1)2016 Dec 23.
Article
em En
| MEDLINE
| ID: mdl-28025533
ABSTRACT
Five new pyran rings containing polyketides, penicipyrans A-E (1-5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher's method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC50 values of 4.4 and 8.5 µM, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicillium
/
Piranos
/
Policetídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article