Eradication of minimal residual disease improves overall and progression-free survival in patients with chronic lymphocytic leukaemia, evidence from NCRN CLL207: a phase II trial assessing alemtuzumab consolidation.

Varghese, Abraham M; Howard, Dena R; Pocock, Christopher; Rawstron, Andy C; Follows, George; McCarthy, Helen; Dearden, Claire; Fegan, Christopher; Milligan, Donald; Smith, Alexandra F; Gregory, Walter; Hillmen, Peter

Varghese, Abraham M; Howard, Dena R; Pocock, Christopher; Rawstron, Andy C; Follows, George; McCarthy, Helen; Dearden, Claire; Fegan, Christopher; Milligan, Donald; Smith, Alexandra F; Gregory, Walter; Hillmen, Peter.

Afiliação

Varghese AM; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Howard DR; Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Pocock C; East Kent Hospitals NHS Trust, Canterbury, UK.
Rawstron AC; Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Follows G; Hull York Medical School, University of York, York, UK.
McCarthy H; Addenbrooke's Hospital, Cambridge, UK.
Dearden C; Royal Bournemouth Hospital, Bournemouth, UK.
Fegan C; Royal Marsden Hospital, Sutton, UK.
Milligan D; University Hospital of Wales, Cardiff, UK.
Smith AF; Centre for Haematology and Stem Cell Transplantation, Heartlands Hospital, Birmingham, UK.
Gregory W; Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
Hillmen P; Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.

Br J Haematol ; 176(4): 573-582, 2017 02.

Article em En | MEDLINE | ID: mdl-28032335

Assuntos

Anticorpos Monoclonais Humanizados/uso terapêutico; Leucemia Linfocítica Crônica de Células B/tratamento farmacológico; Leucemia Linfocítica Crônica de Células B/patologia; Neoplasia Residual/tratamento farmacológico; Adulto; Idoso; Alemtuzumab; Anticorpos Monoclonais Humanizados/efeitos adversos; Exame de Medula Óssea; Quimioterapia de Consolidação; Intervalo Livre de Doença; Feminino; Humanos; Leucemia Linfocítica Crônica de Células B/mortalidade; Masculino; Pessoa de Meia-Idade; Neoplasia Residual/prevenção & controle; Recidiva; Taxa de Sobrevida; Resultado do Tratamento

Palavras-chave

alemtuzumab; chronic lymphocytic leukaemia; minimal residual disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Neoplasia Residual / Anticorpos Monoclonais Humanizados Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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