Cubosomes for in vivo fluorescence lifetime imaging.
Nanotechnology
; 28(5): 055102, 2017 Feb 03.
Article
em En
| MEDLINE
| ID: mdl-28032617
ABSTRACT
Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolved measurements of fluorescence after the intravenous injection of cubosomes revealed that the dye rapidly accumulated mainly in the liver, while lifetimes profiles obtained in vivo allowed for discriminating between free dye or dye embedded within the cubosome nanostructure after injection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbocianinas
/
Espectroscopia de Luz Próxima ao Infravermelho
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Nanopartículas
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Imagem Óptica
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Corantes Fluorescentes
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Lipossomos
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article