Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda.
J Infect Dis
; 215(4): 631-635, 2017 02 15.
Article
em En
| MEDLINE
| ID: mdl-28039354
ABSTRACT
We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistance mutations were common, with apparent emergence of mutations (pfdhfr 164L; pfdhps 581G) associated with high-level resistance. K13 mutations linked to artemisinin resistance were uncommon and did not increase over time. Changing malaria treatment practices have been accompanied by profound changes in markers of resistance.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Resistência a Medicamentos
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Genes de Protozoários
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Antimaláricos
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adolescent
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Female
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Humans
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article