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Thyroid hormone level is associated with the frequency and severity of Guillain-Barré syndrome.
Huang, Yuanyuan; Ying, Zhaojian; Chen, Zhibo; Xiang, Weiwei; Su, Zhongqian; Quan, Weiwei; Weng, Yiyun; Zhang, Xu.
Afiliação
  • Huang Y; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Ying Z; b Department of Respiratory and Critical Care Medicine , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Chen Z; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Xiang W; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Su Z; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Quan W; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Weng Y; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
  • Zhang X; a Department of Neurology , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.
Int J Neurosci ; 127(10): 893-899, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28042737
OBJECTIVE: Guillain-Barré syndrome (GBS) is a neurodegenerative and inflammatory demyelination disorder, and oxidative stress is concerned with the pathogenesis of the disease. Also, we found that thyroid hormone level is correlated to the oxidative and antioxidant status in previous studies. Our study was aimed to find the possible relationship between the frequency and severity of GBS and thyroid hormone levels. MATERIALS AND METHODS: We measured serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in 238 individuals, including 90 GBS, 44 multiple sclerosis and 104 healthy controls. RESULTS: Our findings demonstrate that the patients with GBS had lower TSH and higher FT4, FT4/FT3 than healthy controls in the normal range. Furthermore, it was also shown in our study that TSH levels in patients with GBS were correlated with disease severity measured by the Hughes Functional Grading Scale. CONCLUSION: Lower TSH, higher FT4 and FT4/FT3 stand for the oxidative status and are associated with the incidence and severity of GBS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiroxina / Tri-Iodotironina / Tireotropina / Síndrome de Guillain-Barré Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiroxina / Tri-Iodotironina / Tireotropina / Síndrome de Guillain-Barré Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article