Expression of Monomeric C-Reactive Protein in Infarcted Brain Tissue from Patients with Alzheimer's Disease.
Turk Patoloji Derg
; 33(1): 25-29, 2017.
Article
em En
| MEDLINE
| ID: mdl-28044308
ABSTRACT
OBJECTIVE:
We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and aberrant vascular development we identified a small group of post-mortem brain samples from individuals who had Alzheimer's disease and evidence of tissue infarction/ micro-infarction on histological examination. MATERIAL ANDMETHOD:
We used immunohistochemistry staining to identify the monomeric-C-reactive protein expressed in the infarcted brain tissues.RESULTS:
We showed that monomeric-C-reactive protein deposition was highest in those regions affected by stroke or vascular disruption, and that within those same areas, there was more interaction and co-localization between major classical proteins of neurodegeneration (ß-amyloid and tau).CONCLUSION:
We hypothesise that vascular disruption and concomitant release of monomeric-C-reactive protein within the brain tissue could exacerbate ongoing neurological damage via stimulation of neuro-inflammation and from direct consequences of its action on both neuronal and vascular cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Infarto Encefálico
/
Doença de Alzheimer
Limite:
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article