The impact of age on complications, survival, and cause of death following colon cancer surgery.
Br J Cancer
; 116(3): 389-397, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-28056465
ABSTRACT
BACKGROUND:
Given scarce data regarding the relationship among age, complications, and survival beyond the 30-day postoperative period for oncology patients in the United States, this study identified age-related differences in complications and the rate and cause of 1-year mortality following colon cancer surgery.METHODS:
The NY State Cancer Registry and Statewide Planning and Research Cooperative System identified stage I-III colon cancer resections (2004-2011). Multivariable logistic regression and survival analyses assessed the relationship among age (<65, 65-74, ⩾75), complications, 1-year survival, and cause of death.RESULTS:
Among 24 426 patients surviving >30 days, 1-year mortality was 8.5%. Older age groups had higher complication rates, and older age and complications were independently associated with 1-year mortality (P<0.0001). Increasing age was associated with a decrease in the proportion of deaths from colon cancer with a concomitant increase in the proportion of deaths from cardiovascular disease. Older age and sepsis were independently associated with higher risk of colon cancer-specific death (65-74 HR=1.59, 95% CI=1.26-2.00; ⩾75 HR=2.57, 95% CI=2.09-3.16; sepsis HR=2.58, 95% CI=2.13-3.11) and cardiovascular disease-specific death (65-74 HR=3.72, 95% CI=2.29-6.05; ⩾75 HR=7.02, 95% CI=4.44-11.10; sepsis HR=2.33, 95% CI=1.81-2.99).CONCLUSIONS:
Older age and sepsis are associated with higher 1-year overall, cancer-specific, and cardiovascular-specific mortality, highlighting the importance of geriatric assessment, multidisciplinary care, and cardiovascular optimisation for older patients and those with infectious complications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Envelhecimento
/
Causas de Morte
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Neoplasias do Colo
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article