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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding.
Koenig, Patrick; Lee, Chingwei V; Walters, Benjamin T; Janakiraman, Vasantharajan; Stinson, Jeremy; Patapoff, Thomas W; Fuh, Germaine.
Afiliação
  • Koenig P; Department of Antibody Engineering, Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080; koenig.patrick@gmail.com germainefuh@gmail.com.
  • Lee CV; Department of Antibody Engineering, Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
  • Walters BT; Department of Early-Stage Pharmaceutical Development, Pharma Technical Development, Genentech, Inc., South San Francisco, CA 94080.
  • Janakiraman V; Department of Molecular Biology, Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
  • Stinson J; Department of Molecular Biology, Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080.
  • Patapoff TW; Department of Early-Stage Pharmaceutical Development, Pharma Technical Development, Genentech, Inc., South San Francisco, CA 94080.
  • Fuh G; Department of Antibody Engineering, Genentech Research and Early Development, Genentech, Inc., South San Francisco, CA 94080; koenig.patrick@gmail.com germainefuh@gmail.com.
Proc Natl Acad Sci U S A ; 114(4): E486-E495, 2017 01 24.
Article em En | MEDLINE | ID: mdl-28057863
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas / Anticorpos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas / Anticorpos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article