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Biomimetic spinning of artificial spider silk from a chimeric minispidroin.
Andersson, Marlene; Jia, Qiupin; Abella, Ana; Lee, Xiau-Yeen; Landreh, Michael; Purhonen, Pasi; Hebert, Hans; Tenje, Maria; Robinson, Carol V; Meng, Qing; Plaza, Gustavo R; Johansson, Jan; Rising, Anna.
Afiliação
  • Andersson M; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Jia Q; Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, P.R. China.
  • Abella A; ETSI de Caminos and Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain.
  • Lee XY; ETSI de Caminos and Center for Biomedical Technology, Universidad Politécnica de Madrid, Madrid, Spain.
  • Landreh M; Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK.
  • Purhonen P; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
  • Hebert H; School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
  • Tenje M; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
  • Robinson CV; School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
  • Meng Q; Department of Engineering Sciences, SciLifeLab, Uppsala University, Uppsala, Sweden.
  • Plaza GR; Department of Biomedical Engineering, Lund University, Lund, Sweden.
  • Johansson J; Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK.
  • Rising A; Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, P.R. China.
Nat Chem Biol ; 13(3): 262-264, 2017 03.
Article em En | MEDLINE | ID: mdl-28068309
ABSTRACT
Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomimética / Fibroínas Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomimética / Fibroínas Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article