Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus.
Pak J Med Sci
; 32(6): 1522-1527, 2016.
Article
em En
| MEDLINE
| ID: mdl-28083057
ABSTRACT
OBJECTIVE:
To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM).METHODS:
After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology.RESULTS:
Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant.CONCLUSION:
Metformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article