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Stiffer double-stranded DNA in two-dimensional confinement due to bending anisotropy.
Salari, H; Eslami-Mossallam, B; Ranjbar, H F; Ejtehadi, M R.
Afiliação
  • Salari H; Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran.
  • Eslami-Mossallam B; Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, the Netherlands.
  • Ranjbar HF; Institute of Complex Systems (ICS-2), Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52425 Jülich, Germany.
  • Ejtehadi MR; Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran and School of Nano Science, Institute for Research in Fundamental Sciences (IPM), Tehran 19395-5531, Iran.
Phys Rev E ; 94(6-1): 062407, 2016 Dec.
Article em En | MEDLINE | ID: mdl-28085439
Using analytical approach and Monte Carlo (MC) simulations, we study the elastic behavior of the intrinsically twisted elastic ribbons with bending anisotropy, such as double-stranded DNA (dsDNA), in two-dimensional (2D) confinement. We show that, due to the bending anisotropy, the persistence length of dsDNA in 2D conformations is always greater than three-dimensional (3D) conformations. This result is in consistence with the measured values for DNA persistence length in 2D and 3D in equal biological conditions. We also show that in two dimensions, an anisotropic, intrinsically twisted polymer exhibits an implicit twist-bend coupling, which leads to the transient curvature increasing with a half helical turn periodicity along the bent polymer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Modelos Moleculares / Anisotropia Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Modelos Moleculares / Anisotropia Tipo de estudo: Health_economic_evaluation Idioma: En Ano de publicação: 2016 Tipo de documento: Article