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The effect of intradetrusor botulinum neurotoxin type A on urinary NGF, TGF BETA-1, TIMP-2 levels in children with neurogenic detrusor overactivity due to myelodysplasia.
Top, Tuncay; Sekerci, Cagri Akin; Isbilen-Basok, Banu; Tanidir, Yiloren; Tinay, Ilker; Isman, Ferruh Kemal; Akbal, Cem; Simsek, Ferruh; Tarcan, Tufan.
Afiliação
  • Top T; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
  • Sekerci CA; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
  • Isbilen-Basok B; Deparment of Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey.
  • Tanidir Y; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
  • Tinay I; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
  • Isman FK; Department of Biochemistry, School of Medicine, Medeniyet University, Istanbul, Turkey.
  • Akbal C; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
  • Simsek F; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
  • Tarcan T; Department of Urology, School of Medicine, Marmara University, Istanbul, Turkey.
Neurourol Urodyn ; 36(7): 1896-1902, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28090659
ABSTRACT

AIMS:

The aim of this study was to determine the value of urine nerve growth factor (NGF), transforming growth factor beta 1 (TGF-Beta-1), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) levels to predict the urodynamic profile before and after botulinum neurotoxin type A (BoNT-A) treatment in children with myelodysplasia.

METHODS:

This prospective study included 15 children with myelodysplasia who underwent intradetrusor BoNT-A injections due to neurogenic detrusor overactivity (NDOA). Urine samples of each child were collected before and after BoNT-A injections, specifically at the first and third postoperative months. Urine samples were analyzed with ELISA method and NGF, TGF-Beta-1, and TIMP-2 levels were measured. Urine marker levels and clinical findings were assessed for statistical significance with Wilcoxon Signed Ranks Test and Friedman Test.

RESULTS:

A total of 15 children (5 boys and 10 girls) were assigned as the study group. Mean age of the patients was 7.1 ± 2.5 years (range 2.5-11). A statistically significantly decline was observed in urinary TGF-Beta-1 and NGF levels following BoNT-A injections, compared to the preoperative levels (P < 0.05). TIMP-2 levels also tend to decrease following BoNT-A injections but this was not statistically significant compared to the preoperative levels.

CONCLUSION:

This preliminary study, suggests urinary TGF-Beta-1 and NGF as a potent marker in children with NDOA, as they decline following BoNT-A injection. Further studies are needed in identifying their special role in assessing treatment success after invasive interventions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bexiga Urinaria Neurogênica / Toxinas Botulínicas Tipo A / Bexiga Urinária Hiperativa / Inibidores da Liberação da Acetilcolina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bexiga Urinaria Neurogênica / Toxinas Botulínicas Tipo A / Bexiga Urinária Hiperativa / Inibidores da Liberação da Acetilcolina Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article