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Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's ß-Amyloid Aggregation.
Kuk, Sukeun; Lee, Byung Il; Lee, Joon Seok; Park, Chan Beum.
Afiliação
  • Kuk S; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
  • Lee BI; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
  • Lee JS; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
  • Park CB; Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Small ; 13(11)2017 03.
Article em En | MEDLINE | ID: mdl-28092125
ABSTRACT
Rose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aß aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aß self-assembly under NIR irradiation by generating 1 O2 . Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aß-induced cytotoxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Nanopartículas / Doença de Alzheimer / Agregados Proteicos / Raios Infravermelhos Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Nanopartículas / Doença de Alzheimer / Agregados Proteicos / Raios Infravermelhos Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article