Synthetic lethality: emerging targets and opportunities in melanoma.
Pigment Cell Melanoma Res
; 30(2): 183-193, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28097822
ABSTRACT
Great progress has been made in the treatment of melanoma through use of targeted therapies and immunotherapy. One approach that has not been fully explored is synthetic lethality, which exploits somatically acquired changes, usually driver mutations, to specifically kill tumour cells. We outline the various approaches that may be applied to identify synthetic lethal interactions and define how these interactions may drive drug discovery efforts.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
/
Terapia de Alvo Molecular
/
Mutações Sintéticas Letais
/
Melanoma
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article