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A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.
Martín-Gago, Pablo; Fansa, Eyad K; Klein, Christian H; Murarka, Sandip; Janning, Petra; Schürmann, Marc; Metz, Malte; Ismail, Shehab; Schultz-Fademrecht, Carsten; Baumann, Matthias; Bastiaens, Philippe I H; Wittinghofer, Alfred; Waldmann, Herbert.
Afiliação
  • Martín-Gago P; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Fansa EK; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227, Dortmund, Germany.
  • Klein CH; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Murarka S; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Janning P; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Schürmann M; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Metz M; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Ismail S; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227, Dortmund, Germany.
  • Schultz-Fademrecht C; Lead Discovery Center GmbH, 44227, Dortmund, Germany.
  • Baumann M; Lead Discovery Center GmbH, 44227, Dortmund, Germany.
  • Bastiaens PI; Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, 44227, Dortmund, Germany.
  • Wittinghofer A; TU Dortmund, Faculty of Chemistry and Chemical Biology, 44227, Dortmund, Germany.
  • Waldmann H; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227, Dortmund, Germany.
Angew Chem Int Ed Engl ; 56(9): 2423-2428, 2017 02 20.
Article em En | MEDLINE | ID: mdl-28106325
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article