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Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.
Rombouts, Frederik J R; Andrés, José-Ignacio; Ariza, Manuela; Alonso, José Manuel; Austin, Nigel; Bottelbergs, Astrid; Chen, Lu; Chupakhin, Vladimir; Cleiren, Erna; Fierens, Katleen; Fontana, Alberto; Langlois, Xavier; Leenaerts, Joseph E; Mariën, Jonas; Martínez Lamenca, Carolina; Salter, Rhys; Schmidt, Mark E; Te Riele, Paula; Wintmolders, Cindy; Trabanco, Andrés A; Zhang, Wei; Macdonald, Gregor; Moechars, Dieder.
Afiliação
  • Rombouts FJ; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Andrés JI; Discovery Sciences, Janssen Research & Development, Janssen-Cilag S. A. , C/Jarama 75A, 45007 Toledo, Spain.
  • Ariza M; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Alonso JM; Discovery Sciences, Janssen Research & Development, Janssen-Cilag S. A. , C/Jarama 75A, 45007 Toledo, Spain.
  • Austin N; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Bottelbergs A; Discovery Sciences, Janssen Research & Development, Janssen-Cilag S. A. , C/Jarama 75A, 45007 Toledo, Spain.
  • Chen L; Isotope Chemistry and Biotransformation, Janssen Research & Development , Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States.
  • Chupakhin V; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Cleiren E; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Fierens K; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Fontana A; Discovery Sciences, Janssen Research & Development, Janssen-Cilag S. A. , C/Jarama 75A, 45007 Toledo, Spain.
  • Langlois X; Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Leenaerts JE; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Mariën J; Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Martínez Lamenca C; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Salter R; Isotope Chemistry and Biotransformation, Janssen Research & Development , Welsh & McKean Roads, Spring House, Pennsylvania 19477, United States.
  • Schmidt ME; Neuroscience Experimental Medicine, Janssen Early Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Te Riele P; Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Wintmolders C; Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Trabanco AA; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S. A. , C/Jarama 75A, 45007 Toledo, Spain.
  • Zhang W; Neuroscience Biomarker Research, Janssen Research & Development , 3210 Merryfield Row, San Diego, California 92121, United States.
  • Macdonald G; Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Moechars D; Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica N. V. , Turnhoutseweg 30, B-2340 Beerse, Belgium.
J Med Chem ; 60(4): 1272-1291, 2017 02 23.
Article em En | MEDLINE | ID: mdl-28106992
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Peptídeos beta-Amiloides / Proteínas tau / Tomografia por Emissão de Pósitrons / Doença de Alzheimer / Agregação Patológica de Proteínas / Naftiridinas Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Peptídeos beta-Amiloides / Proteínas tau / Tomografia por Emissão de Pósitrons / Doença de Alzheimer / Agregação Patológica de Proteínas / Naftiridinas Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article