Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells.
Vet Microbiol
; 199: 8-14, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-28110790
ABSTRACT
Mink enteritis virus (MEV) is one of the most important viral pathogens causing serious disease in mink. Type I interferon (IFN) plays a critical role in antiviral innate immunity and, for successful infection, many viruses have evolved evasive strategies against it. Here, we show that MEV infection does not evoke IFN or interferon-stimulated genes (ISGs) responses in feline kidney (CRFK) cells, and that MEV suppresses IFN production in both poly IC-stimulated and untreated cells. In CRFK cells pre-exposure to IFN, show that infection with, and replication of, MEV remain unaffected. This inhibition appears to be mediated by the MEV nonstructural protein (NS1) with its ORI-binding domain playing a major role.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon Tipo I
/
Vírus da Enterite do Vison
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Panleucopenia Felina
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article