Identification of a gene encoding a membrane-anchored toll-like receptor 5 (TLR5M) in Oplegnathus fasciatus that responds to flagellin challenge and activates NF-&#954;B.

Umasuthan, Navaneethaiyer; Bathige, S D N K; Thulasitha, William Shanthakumar; Jayasooriya, R G P T; Shin, Younhee; Lee, Jehee

Identification of a gene encoding a membrane-anchored toll-like receptor 5 (TLR5M) in Oplegnathus fasciatus that responds to flagellin challenge and activates NF-κB.

Umasuthan, Navaneethaiyer; Bathige, S D N K; Thulasitha, William Shanthakumar; Jayasooriya, R G P T; Shin, Younhee; Lee, Jehee.

Afiliação

Umasuthan N; Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-8570, Japan.
Bathige SDNK; Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Fish Vaccine Development Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea.
Thulasitha WS; Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Fish Vaccine Development Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea.
Jayasooriya RGPT; Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea.
Shin Y; Insilicogen Inc., Giheung-gu, Yongin-si, Gyeonggi-do, 16954, Republic of Korea. Electronic address: myhshin@insilicogen.com.
Lee J; Department of Marine Life Sciences, School of Marine Biomedical Sciences, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Fish Vaccine Development Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea. Electronic address: jehee@jej

Fish Shellfish Immunol ; 62: 276-290, 2017 Mar.

Article em En | MEDLINE | ID: mdl-28111358

Assuntos

Proteínas de Peixes/genética; Flagelina/farmacologia; Fator 88 de Diferenciação Mieloide/genética; NF-kappa B/genética; Perciformes/genética; Receptor 5 Toll-Like/genética; Sequência de Aminoácidos; Animais; Sequência de Bases; Clonagem Molecular; DNA Complementar/genética; DNA Complementar/metabolismo; Proteínas de Peixes/química; Proteínas de Peixes/metabolismo; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Perciformes/imunologia; Perciformes/metabolismo; Filogenia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Salmonella typhimurium/fisiologia; Alinhamento de Sequência/veterinária; Receptor 5 Toll-Like/química; Receptor 5 Toll-Like/metabolismo

Palavras-chave

Flagellin (FLA) sensing; Genomic evolution; Membrane-anchored toll-like receptor 5 (TLR5M); Myeloid differentiation primary response gene 88 (MyD88); NF-κB activation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Perciformes / NF-kappa B / Proteínas de Peixes / Receptor 5 Toll-Like / Fator 88 de Diferenciação Mieloide / Flagelina Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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