An indirect method for in vivo T2 mapping of [1-13 C] pyruvate using hyperpolarized 13 C CSI.
NMR Biomed
; 30(5)2017 May.
Article
em En
| MEDLINE
| ID: mdl-28111820
ABSTRACT
An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpolarized 13 C CSI data. The concept is verified with phantom studies. Simulations were performed to evaluate the extent of T2 estimation accuracy due to errors in the other measurements. Also, bias in the 13 C T2 * estimation from the 13 C CSI data was studied. In vivo experiments were performed from the brains of normal rats and a rat with C6 glioma. Simulation results indicate that the proposed method provides accurate and unbiased 13 C T2 values within typical experimental settings. The in vivo studies found that the estimated T2 of [1-13 C] pyruvate using the indirect method was longer in tumor than in normal tissues and gave values similar to previous reports. This method can estimate localized T2 relaxation times from multiple voxels using conventional hyperpolarized 13 C CSI and can potentially be used with time resolved fast CSI.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Processamento de Sinais Assistido por Computador
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Neoplasias Encefálicas
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Biomarcadores Tumorais
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Ácido Pirúvico
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Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
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Glioma
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article