Short bowel syndrome results in increased gene expression associated with proliferation, inflammation, bile acid synthesis and immune system activation: RNA sequencing a zebrafish SBS model.

Schall, Kathy A; Thornton, Matthew E; Isani, Mubina; Holoyda, Kathleen A; Hou, Xiaogang; Lien, Ching-Ling; Grubbs, Brendan H; Grikscheit, Tracy C

Schall, Kathy A; Thornton, Matthew E; Isani, Mubina; Holoyda, Kathleen A; Hou, Xiaogang; Lien, Ching-Ling; Grubbs, Brendan H; Grikscheit, Tracy C.

Afiliação

Schall KA; Division of Pediatric Surgery and Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Thornton ME; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Isani M; Division of Pediatric Surgery and Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Holoyda KA; Division of Pediatric Surgery and Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Hou X; Division of Pediatric Surgery and Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Lien CL; Division of Cardiothoracic Surgery, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Grubbs BH; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA.
Grikscheit TC; Division of Pediatric Surgery and Developmental Biology and Regenerative Medicine, Saban Research Institute, Children's Hospital Los Angeles and USC Keck School of Medicine, Los Angeles, CA, 90027, USA. tgrikscheit@chla.usc.edu.

BMC Genomics ; 18(1): 23, 2017 01 25.

Article em En | MEDLINE | ID: mdl-28118819

Assuntos

Ácidos e Sais Biliares/metabolismo; Expressão Gênica; Sistema Imunitário/imunologia; Sistema Imunitário/metabolismo; Síndrome do Intestino Curto/etiologia; Síndrome do Intestino Curto/metabolismo; Animais; Proliferação de Células; Análise por Conglomerados; Modelos Animais de Doenças; Perfilação da Expressão Gênica; Inflamação/genética; Inflamação/imunologia; Inflamação/metabolismo; Inflamação/patologia; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patologia; Análise de Sequência de RNA; Síndrome do Intestino Curto/patologia; Peixe-Zebra

Palavras-chave

Cell proliferation; Inflammation; Innate and adaptive immunity; Intestinal resection; RNA sequencing; Short bowel syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Intestino Curto / Ácidos e Sais Biliares / Expressão Gênica / Sistema Imunitário Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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