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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.
Winerdal, Max; Urmaliya, Vijay; Winerdal, Malin E; Fredholm, Bertil B; Winqvist, Ola; Ådén, Ulrika.
Afiliação
  • Winerdal M; Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden.
  • Urmaliya V; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Winerdal ME; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Fredholm BB; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Winqvist O; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Ådén U; Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden.
PLoS One ; 12(1): e0170545, 2017.
Article em En | MEDLINE | ID: mdl-28129361
ABSTRACT
In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cafeína / Fármacos Neuroprotetores / Hipóxia-Isquemia Encefálica / Neurônios Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cafeína / Fármacos Neuroprotetores / Hipóxia-Isquemia Encefálica / Neurônios Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article