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Diverse structural approaches to haem appropriation by pathogenic bacteria.
Hare, Stephen A.
Afiliação
  • Hare SA; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Biochim Biophys Acta Proteins Proteom ; 1865(4): 422-433, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28130069
ABSTRACT
The critical need for iron presents a challenge for pathogenic bacteria that must survive in an environment bereft of accessible iron due to a natural low bioavailability and their host's nutritional immunity. Appropriating haem, either direct from host haemoproteins or by secreting haem-scavenging haemophores, is one way pathogenic bacteria can overcome this challenge. After capturing their target, haem appropriation systems must remove haem from a high-affinity binding site (on the host haemoprotein or bacterial haemophore) and transfer it to a binding site of lower affinity on a bacterial receptor. Structural information is now available to show how, using a combination of induced structural changes and steric clashes, bacteria are able to extract haem from haemophores, haemopexin and haemoglobin. This review focuses on structural descriptions of these bacterial haem acquisition systems, summarising how they bind haem and their target haemoproteins with particularly emphasis on the mechanism of haem extraction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Infecções Bacterianas / Proteínas de Bactérias / Heme Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Infecções Bacterianas / Proteínas de Bactérias / Heme Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article